Following whole-body deletion of Gclc , adult mice rapidly lose weight and die, but not before showing a reduction in circulating triglyceride levels
Glutathione S -transferase P1 (GSTP1), the gene encoding the pi-class GST, is frequently inactivated by acquired somatic CpG island promoter hypermethylation in multiple cancer subtypes including prostate, breast, liver, and blood cancers
168 Canolol, a phenolic compound derived from rapeseed oil, provided significant protection against ethanol-induced gastric damage by enhancing antioxidant defenses (elevating glutathione, catalase (CAT), and superoxide dismutase (SOD)) and inhibiting the activation of pro-inflammatory pathways, especially p38 MAPK and NF-B
308 The resulting Arg-CysO 2 (H) acts as an N-degron, which is identified by UBR1 and UBR2 for ubiquitylation and subsequent degradation